Contact Us Careers CN
Home About BioEngine Company Overview
About BioEngine
Company Overview

Shanghai BioEngine Sci-Tech Co., Ltd was founded on December 24, 2014, in Shanghai China. We specialize in providing high-quality & cost-effective cell culture media and related technical services in antibody, vaccine, and cell & gene therapy fields. The headquarter and R&D center are located in Shanghai Zhangjiang Hi-Tech Park, and the Phase II production base (Shanghai Beijin Biotech Co., Ltd.) is located in Jinshan, Shanghai.


Since the establishment of BioEngine in 2014, we have grown rapidly and developed nearly 100 types of serum-free media for different cell lines, including Eden series serum-free medium for CHO cells, HIPP series serum-free medium for immune effector cells for cell therapy, serum-free medium for vaccine production of Vero, HEK293, MDCK, PK15, BHK, MDBK, insect cells, etc. Our media supports high-density cell culture and efficient expansion, outperforming other well-known media products. Our products make cell products easier to be purified and processed in downstream process, which is effectively improving the safety and yield of cell products, as well as significantly reducing production costs for customers. Our product quality and technical service level have outperformed similar imported products and are highly appreciated by domestic biopharmaceutical companies.


Up to now, BioEngine has supported more than 80 clinical projects in the biopharma industry, including antibodies, vaccines, and cell and gene therapy, and has provided nearly 100 cell culture technology services, with many innovative project achievements domestically and internationally. In the field of antibody, BioEngine helps customers to launch the antibody fusion protein drug. In the field of vaccine, the company has completed the project of producing human/avian influenza vaccine based on MDCK cell serum-free suspension culture technology  the first domestic human vaccine (phase III clinical) project based on VERO cell serum-free culture technology as early as 2019. In the field of cell therapy, BioEngine has independently developed the HIPP-T009 series immune effector cell culture mediumas early as 2019. It has become the first completely serum-free medium launched in China for high-density culture and maintenance of CAR-T cells and NK cells, which is also the domestic culture medium used for cell therapy clinical trial declaration (CTA) and passed the CDE audit in China.


In the end of 2021, the Phase II culture media production base (Shanghai Beijin Biotech Co., Ltd) commenced full operation. This production base is an advanced factory that is built according to ISO13485:2016 quality management system, GMP, and MDSAP multi-system requirements, using the Lean Six Sigma (LSS) system for production management. The production base has realized the consistency amplification of the low-temperature CMPM (Cone Mixing/ Pin Mill) powder process at the level of 1,000 liters, 10,000 liters, and 100,000 liters, and the maximum production batch can reach 100,000 liters. The annual capacity of the powder medium is 55 million liters, and the annual capacity of the liquid medium is 250,000 liters. Our products meet the requirements of culture media for US FDA certification and EU product registration declaration and other related regulations.

BioEngine is dedicated to empowering local innovative biopharmaceutical products such as antibodies, vaccines, and cell therapies to go abroad and realize the dual declarations of China-US and China-EU with our stable and reliable high-quality culture media. 

BioEngine is committed to empowering the development and production of innovative biopharmaceutical products with consistent and reliable high-quality culture media products and services for the benefit of human health worldwide.

  • +

    years in cell culture research

  • +

    clinical trial projects

  • +

    serum-free medium products

  • +

    China & global partners

  • m2

    advanced culture medium production
    factory in compliance with GMP

Applications
  • For Antibodies

    BioEngine has developed the Eden series CHO Cell CD medium by using its huge formulation library and patented iBioG-Med development platform. This series can support the high-density culture of CHO cells and the efficient production of therapeutic proteins, and the expression and quality of the protein products are comparable to global brands. This series media have a large number of successful application cases for mainstream production cell lines.

  • For Vaccines

    Over the past 30 years, the R&D team has strenuously cultivated in the field of vaccines and developed multiple series of serum-free media with independent intellectual property rights according to the cell types, vaccines, and production lines. These media products can support the large-scale and high-density culture of cells and the efficient production of vaccines, basically meeting the requirements of all vaccine products in the R&D and production process.

  • For Cell and Gene Therapy (CGT)

    In the field of cell and gene therapy (CGT), BioEngine has developed multiple serum-free mediums with independent intellectual property rights. These media are applied to cell culture research and production in the field of CGT and have supported to completion of IND projects for many CGT companies.

  • Classical Cell Culture Medium

    We offer classical cell culture media, including RPMI 1640, MEM, DMEM, Ham's F12, IMDM, M199, etc.

Main facilities
Home office -Shanghai Minhang Phase II production base - Shanghai Jinshan R&D Center Introduction

Home office -Shanghai Minhang

The home office and R&D center of BioEngine are located in Shanghai Lingang Pujiang International Life Health City. We have attracted high-level talents from top domestic and foreign universities and foreign companies, and built a team of nearly 150 people to provide professional and efficient "China Intelligent Manufacturing" serum-free medium solutions for biopharmaceutical companies and institutions.

In order to provide prompt service, besides Shanghai, BioEngine has set up several sales and service sites in Beijing, Guangzhou, Chengdu, Suzhou, Inner Mogolia, etc.

Phase II production base - Shanghai Jinshan

Shanghai Beijin Biotech Co., Ltd., (Beijin in short)

Beijin, a wholly owned subsidiary of BioEngine, is located in Zhangjiang Industrial Park, Jinshan, Shanghai. It is the Phase II supply chain center and medium production base of BioEngine.

 

R&D Center Introduction

The laboratory of the R&D center covers an area of more than 3000 m2 and is built with the core functions of cell culture, high-throughput screening, bioreactor operation, product purification, and drug quality analysis. The laboratory has been equipped with the necessary instruments and equipment commonly used in the bio-pharma field to meet the needs of medium formulation design, process development, and providing cell culture technical services. These devices include but are not limited to: bioreactors, cell culture shakers, CO2 incubators, biosafety cabinets, cell counters, microscopes, AKTA protein purification systems, LC-MS, HPLC, UPLC, CE, plate readers, microplate washer&stacker and electroporation system.

The R&D center has 30+ technical talents from domestic and foreign universities. The team has a solid technical foundation in animal cell culture process development and optimization, personalized serum-free medium design and development, bioreactor design scale-up and optimized operation, and cell expression product quality optimization and control. We have accumulated extensive experience in large-scale, high-density, serum-free culture technologies for animal cells and basic research and application development for bioreactor engineering. Many of our previous research results have been or are being piloted and industrialized by leading biopharmaceutical companies in China. We assist multiple production processes in multiple companies to achieve 10 million cell densities and thousand liters reactor sizes while maintaining a high quality of pharmaceutical products. In addition, the R&D center also undertakes to apply for intellectual property protection for the above-involved technologies and products.

History
Particular Year
  • 1986

    Technical team for large-scale culture of animal cells established to enter antibody and vaccine industry

  • 1995

    Opened up the research direction of stem cell and tissue engineering

  • 2014

    Shanghai BioEngine Sci-Tech Co., Ltd  was established

  • 2015

    Presided Over Zhangjiang Major Development Project of Gov. Sp. Fund
    Xeno series serum-free medium for MDCK cells launched

  • 2016

    Round A Financing (Shanghai STVC Group)
    Zhangjiang Pilot Production and R&D Center launched

  • 2017

    Chinese culture media company passed by ISO13485 QS Certificated (BSI Audit)
    Low serum culture medium for BHK cells launched

  • 2018

    Eden series of CD medium for CHO cells for antibody production launched
    HIPP series of serum-free medium for immune effector cells for cell therapy launched
    Vigor series of serum-free medium for insect cells launched
    Bofit series of serum-free medium for MDBK cells launched
    Tac series of serum-free medium for BHK cells launched
    Proli series of serum-free medium for PK15 cells launched
    Celer series of serum-free medium for 293 cells launched

  • 2019

    Honored as "SHANGHAI TECHNICAL INNOVATION ENTERPRISE"
    Round B financing  (China SME Development Fund Co., Ltd.)
    Eden series of perfusion medium for CHO cells launched
    Pesche series of serum-free medium for Vero cells launched

  • 2020

    Won the Title of Shanghai "NEW SPECIALIZED" Small and Medium-sized Enterprise
    Human rabies vaccine production project using Pesche series of serum-free medium for Vero cells successfully entered clinical phase III.
    Personalized precision therapy program using HIPP-T009 serum-free medium for immune effector cells enterd clinical trials for the first time in China

  • 2021

    Round B+ Financing completed. (Shanghai Hankang Equity Investment Management Co., Ltd)
    Phase II manufacturing site (Shanghai Beijin Biotech Co., Ltd.) launched.

  • 2022

    Round B++ financing completed(Legend Capital lead invest)

Open

Let us contact you

We have a professional technical team to provide high quality one-stop cell culture service from process development
and optimization, medium formulation design to medium processing and manufacturing for all biopharmaceutical companies.

If you have any question, please click "Quick Message" and leave your message,  we will reply to you as soon as possible.
If anything urgent, please call (86)21-68582660-2792.

BioEngine

3F&4F, Building 3, Lane 396, Lvzhou Ring Road, Minhang District, Shanghai, PRC

(86)21-68582660-2792

globalsales@bio-engine.com.cn

Work hours:9:00-17:00